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Merck

D9268

Diatrizoic acid

≥98% purity, powder

Synonym(s):

Amidotrizoic Acid, NSC 262168

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About This Item

Empirical Formula (Hill Notation):
C11H9I3N2O4
CAS Number:
Molecular Weight:
613.91
EC Number:
MDL number:
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.75

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Product Name

Diatrizoic acid, Iodine-containing contrast agent

Quality Level

form

powder

composition

Water (by Karl Fischer): ≤ 7.1%

concentration

≥98.0% AgNO3

technique(s)

titration: suitable

color

white to off-white

solubility

1 M NH4OH: 100 mg/mL, colorless

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(O)=O)c1I

InChI

1S/C11H9I3N2O4/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18/h1-2H3,(H,15,17)(H,16,18)(H,19,20)

InChI key

YVPYQUNUQOZFHG-UHFFFAOYSA-N

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1 of 4

This Item
1184005B1125D6518
technique(s)

titration: suitable

technique(s)

-

technique(s)

titration: 90% using HCLO4 (Dry Basis)

technique(s)

-

color

white to off-white

color

-

color

white to beige

color

-

concentration

≥98.0% AgNO3

concentration

-

concentration

-

concentration

-

solubility

1 M NH4OH: 100 mg/mL, colorless

solubility

-

solubility

H2O: 50 mg/mL

solubility

1 M HCl: 50 mg/mL, clear, colorless

form

powder

form

-

form

powder

form

powder

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

pharmaceutical (small molecule)

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

General description

Diatrizoic acid is an iodine-containing contrast agent. It is also known as amidotrizoic acid. Diatrizoic acid is one of the trace contaminants of waste water treatment plants.

Application

Diatrizoic acid has been used as a contrast-enhancing fluid for X-ray based measurements.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Correlation of six anthropogenic markers in wastewater, surface water, bank filtrate, and soil aquifer treatment
Scheurer M, et al.
Journal of Environmental Monitoring, 13(4) (2011)
Biodegradability of the X-ray contrast compound diatrizoic acid, identification of aerobic degradation products and effects against sewage sludge micro-organisms
Hai? Anette and K
Chemosphere, 62(2) (2006)
A Mallios et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 41(4), 548-553 (2011-02-01)
Pelvic arteriovenous malformations (AVMs) are difficult to treat. Arterial embolisation is the most common strategy but often has poor results. We report an alternative surgical approach of controlled intra-operative transvenous embolisation with long-term results in seven cases. Between 1980 and
Katharina Fucke et al.
Chemical communications (Cambridge, England), 48(99), 12065-12067 (2012-11-10)
We present three crystal structures of diatrizoic acid (DTA) DMSO solvates illustrating progressive desolvation of the DTA molecule and concomitant increasing degree of DTA self-association. Using these structures, plausible pathways for overcoming the solvation shell of DTA during its crystallisation
Nicolas Anton et al.
International journal of pharmaceutics, 454(1), 143-148 (2013-07-16)
This study proposes a new methodology to evaluate the putative consequences of the long-lasting circulation in the blood pool of nanoparticulate systems widely used in nanomedicine, Indeed, the blood pool contrast agent for micro-computed tomography, i.e. iodinated nano-emulsions, have recently

Questions

  1. Are there any non-ionic iodinated contrast agents, such as Iopamiron?

    1 answer
    1. iopamiron is not available but iodixanol, iopromide, and iohexol can be used as reference standards, which are likely more expensive on a per gram basis due to their intended use. The only other chemical close to iopamiron is ionic rather than non-ionic.

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