12666

Albumin, Human Serum, Fraction V, Low Heavy Metals

• Synonym(s): Albumin, Human Serum, Fraction V, Low Heavy Metals
• CAS Number: 70024-90-7
• UNSPSC Code: 12352202
• NACRES: NA.25
• MDL number: MFCD00081418

Properties

• SMILES string: FC(F)(F)C(F)(F)C(F)(F)F
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• description: Merck USA index - 14, 8468
• assay: ≥95% (SDS-PAGE)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• impurities: ≤5.0% Ash; ≤6% moisture
• pI: 4.7
• solubility: water: 50 mg/mL
• cation traces: heavy metals: ≤20 ppm
• shipped in: ambient
• storage temp.: 2-8°C
• Quality Level: 100

Description

Application

Albumin, Human Serum, Fraction V, Low Heavy Metals has been used:

• as a supplement in double buffer and milliQ-water for in vivo[1]
• in serum-free media for polarized secretion assays in human dermal microvascular endothelial cells[2]
• as a supplement in sodium phosphate buffer for the reconstitution of hormone lysis samples[3]

Biochem/physiol Actions

Human serum albumin (HSA) is very crucial in stabilizing extracellular fluid volume. It functions as an excipient for vaccines and therapeutic protein drugs. HSA serves as a cell culture medium supplement for the synthesis of vaccines and pharmaceuticals.[4] It is useful as a carrier protein for steroids, fatty acids, and thyroid hormones.[4] HSA is used to treat cardiopulmonary bypass, trauma, hemorrhage, and hypoalbuminemia.[5] HSA is useful in biological applications, such as implantable biomaterials, biochromatography, surgical adhesives, and sealants.[5]

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Toxicity: Standard Handling (A)

General description

Human serum albumin (HSA) is an abundant protein found in the plasma.[5] This globular, soluble, and unglycosylated monomeric protein[4], has three homologous domains (I, II, and III).[5][6] These domains have subdomains A and B having common structural motifs. The HSA gene is located on the human chromosome 4q13.3.[6]

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable