07-239

Przeciwciało anty-mGluR7

Upstate^®, from rabbit

• Synonim(y): Anti-GLUR7, Anty-MGLU7, Anty-MGLUR7, Anty-NEDSHBA, Anty-PP1R87
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 19

Właściwości

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: rat
• manufacturer/tradename: Upstate^®
• technique(s): western blot: suitable
• isotype: IgG
• NCBI accession no.: NM_000831
• UniProt accession no.: Q14831
• shipped in: dry ice
• target post-translational modification: unmodified
• Gene Information: human ... GRM7(2917)

Opis

General description

97kDa

Metabotropic glutamate receptor 7 (UniProt: Q14831; also known as mGluR7) is encoded by the GRM7 (also known as GPRC1G, MGLUR7) gene (Gene ID: 2917) in human. GRM7 gene is mapped to human chromosome 3p26. L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. GRM7 belongs to Group III, and members of group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. mGluR7 is a multi-pass membrane protein and is synthesized with a signal peptide (aa 1-34), which is subsequently cleaved off to produce the mature protein (aa 35-915). mGluR7 is expressed in several parts of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. It is located in the presynaptic zone of the synaptic cleft of glutamatergic synapses. Five isoforms of mGluR7 have been described that are produced by alternative splicing. The gene coding MGLUR7 is associated with autism and also participates in schizophrenia and bipolar disorder. Dysregulation of mGluR7 has been implicated in several neuropsychiatric disorders, including anxiety, depression, and fragile X syndrome (FXS), where its modulation by allosteric agents like AMN082 has shown therapeutic potential. Studies suggest that drugs targeting mGluR7: mGluR7 agonists, antagonists, and allosteric modulators may play a role as promising agents for the treatment of central nervous system disorders. (Ref.: Li P., et al. (2024). Ageing Res Rev. 102;102554; Palazzo E., et al. (2016). Curr Neuropharmacol. 14(5); 504-513).

Immunogen

peptyd (C-NSPAAKKKYVSYNN) odpowiadający aminokwasom 899-912 ludzkiego mGluR7

Application

Kategoria badawcza
Neuroscience

Podkategoria badawcza
Ruch pęcherzykowy

Choroby neurodegeneracyjne

Wykrywaj mGluR7 przy użyciu tego przeciwciała anty-mGluR7 zatwierdzonego do stosowania w WB.

Biochem/physiol Actions

mGluR7

Physical form

Chromatografia białka A

Format: Oczyszczony

Preparation Note

2 lata w temperaturze -20°C

Analysis Note

Evaluated by Western Blotting in rat brain microsomal preparation.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected mGluR7 in rat brain microsomal preparation.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

O ile nie określono inaczej w naszym katalogu lub innej dokumentacji firmy dołączonej do produktu(-ów), nasze produkty są przeznaczone wyłącznie do użytku badawczego i nie mogą być wykorzystywane do żadnych innych celów, w tym między innymi do nieautoryzowanych zastosowań komercyjnych, zastosowań diagnostycznych in vitro, zastosowań terapeutycznych ex vivo lub in vivo lub jakiegokolwiek rodzaju konsumpcji lub zastosowania u ludzi lub zwierząt.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• wgk: WGK 1