The testing on the blood-brain barrier permeability of this product has not been conducted. However, according to the following article, this compound is expected to be capable of crossing the blood-brain barrier: J Lipid Res. 2004 Oct;45(10):1952-7. The publication is titled "Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain" and can be found under the PMID: 15258193
190080
AY 9944
A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification.
Synonim(y):
trans-1, 4-bis(2-chlorobenzyloaminometylo)cykloheksan, 2HCl, antagonista sygnalizacji Shh IV, trans-1,4-bis(2-chlorobenzyloaminometylo)cykloheksan, 2HCl, antagonista sygnalizacji Shh IV
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 mg | Sprawdź dostępność w koszyku | 1030,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C22H28Cl2N2 · 2HCl
Numer CAS:
Masa cząsteczkowa:
464.30
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
1030,00 zł
Sprawdź dostępność w koszyku
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Pozwól nam pomócQuality Segment
description
RTECS - GU7025000
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
DMSO: 20 mg/mL, water: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Cl-].[Cl-].Clc1c(cccc1)CNCC2CCC(CC2)CNCc3c(cccc3)Cl.[H+].[H+]
InChI
1S/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H
InChI key
NRVIEWRSGDDWHP-UHFFFAOYSA-N
General description
A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts.
A cell-permeable, amphiphilic diamine that acts as a potent inhibitor of cholesterol biosynthesis and esterification and exhibits teratogenic properties. Specifically blocks 7-dehydro-cholesterol reductase (Δ7-sterol reductase; DHC) activity with IC50= 13 nM. Reported to disrupt Sonic Hedgehog (Shh) signaling during embryogenesis in rats. Also reported to induce a rapid and irreversible reduction in acidic-sphingomyelinase activity in fibroblasts.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
7-dehydrocholesterol reductase (δ7-sterol reductase)
7-dehydrocholesterol reductase (δ7-sterol reductase)
Product does not compete with ATP.
Reversible: no
Target IC50: 13 nM in blocking 7-dehydrocholesterol reductase (δ7-sterol reductase) activity
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Gofflot, F., et al. 2001. Dev. Dyn.220, 99.
Cooper, M.K., et al. 1998. Science280, 1603.
Incardona, J.P., et al. 1998. Development125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem.98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun.15, 455.
Cooper, M.K., et al. 1998. Science280, 1603.
Incardona, J.P., et al. 1998. Development125, 3553.
Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899.
Yoshida, Y. 1985. J. Biochem.98, 1669.
Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun.15, 455.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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Ta pozycja | |||
|---|---|---|---|
| description A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. | description - | description ≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder | description clone SH154, purified from hybridoma cell culture |
| form solid | form - | form lyophilized powder | form buffered aqueous solution |
| assay ≥95% (HPLC) | assay - | assay ≥97% (SDS-PAGE) | assay - |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename - |
| storage temp. 2-8°C | storage temp. -10 to -25°C | storage temp. −20°C | storage temp. −20°C |
| solubility water: 20 mg/mL, DMSO: 20 mg/mL | solubility - | solubility - | solubility - |
Słowo ostrzegawcze
Danger
Kody zagrożeń
Ostrzeżenia
Hazard Classifications
Acute Tox. 3 Oral
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Co się dzieje?
WGK 3
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