Following reconstitution in DMSO, it is recommended to aliquot and freeze stock solutions at -20°C for up to 1 month. The solution stability at -80°C has not been determined for this product.
203391
(−)-Blebbistatin
≥98% (HPLC), solid, ATPase inhibitor, Calbiochem®
Synonim(y):
(-)-Blebbistatin
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 mg | Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o. | 886,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C18H16N2O2
Numer CAS:
Masa cząsteczkowa:
292.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
886,00 zł
Dostępne do wysyłki DZISIAJSzczegóły
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
(-)-Blebistatyna, The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
Quality Segment
assay
≥98% (HPLC)
form
solid
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
methanol: 1.5 mg/mL, 100% DMSO: 100 mg/mL, 90% DMSO: 75 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
N2(CC[C@@]3(C2=Nc4c(cc(cc4)C)C3=O)O)c1ccccc1
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChI key
LZAXPYOBKSJSEX-GOSISDBHSA-N
General description
The active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
Other Notes
Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther.320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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Ta pozycja | ||
|---|---|---|
| description The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes. | description solid, synthetic | description InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II |
| assay ≥98% (HPLC) | assay - | assay ≥97% (HPLC) |
| form solid | form solid | form liquid |
| manufacturer/tradename Calbiochem® | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| storage condition OK to freeze, protect from light | storage condition - | storage condition protect from light, OK to freeze, desiccated (hygroscopic) |
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Klasa składowania
11 - Combustible Solids
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Can this be stored in -80 once in 90%DMSO?
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