232120

Cisplatin

Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.

• Synonym(s): Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum
• Linear Formula: Pt(NH₃)₂Cl₂
• CAS Number: 15663-27-1
• Numer MDL: MFCD00011623
• NACRES: NA.77

Properties

• Poziom jakości: 100
• próba: ≥98% (HPLC)
• forma: solid
• manufacturer/tradename: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: yellow
• rozpuszczalność: PBS with 140 mM NaCl: 1 mg/mL; water with 154 mM NaCl: 1 mg/mL; DMSO: 10 mg/mL
• transport: ambient
• temp. przechowywania: 2-8°C
• InChI: 1S/2Cl.2H3N.Pt/h;;2*1H3;
• InChI key: JFUARQHXOQHNLK-UHFFFAOYSA-N

Description

Opis ogólny

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

A platinum coordination complex with potent antineoplastic activity.



Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

Opakowanie

50 mg in Glass bottle

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Induces apoptosis in cancer cells

Product does not compete with ATP.

Reversible: no

Ostrzeżenie

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Rekonstytucja

Unstable in solution; reconstitute just prior to use.

Inne uwagi

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300 - H315 - H317 - H319 - H334 - H335 - H350
• Zwroty wskazujące środki ostrożności: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable