232120

cis-Diammineplatinum(II) dichloride

≥98% (HPLC), solid, anti-neoplastic agent, Calbiochem

• Synonim(y): Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum
• Wzór liniowy: Pt(NH₃)₂Cl₂
• Numer CAS: 15663-27-1
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00011623
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Nazwa produktu: Cisplatin, Cisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation.
• Quality Segment: 100
• description: Merck USA index - 14, 2317
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: yellow
• solubility: PBS with 140 mM NaCl: 1 mg/mL, water with 154 mM NaCl: 1 mg/mL, DMSO: 10 mg/mL
• shipped in: wet ice
• storage temp.: 2-8°C
• InChI: 1S/2Cl.2H3N.Pt/h;;2*1H3;
• InChI key: JFUARQHXOQHNLK-UHFFFAOYSA-N

Opis

General description

A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.

Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Induces apoptosis in cancer cells

Product does not compete with ATP.

Reversible: no

Preparation Note

Unstable in solution; reconstitute just prior to use.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Ostrzeżenia: P202 - P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Narządy docelowe: Respiratory system
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Kody zagrożeń: H300,H315,H317,H319,H334,H335,H340,H350,H360FD
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3