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236015

COX-2 Inhibitor V, FK3311

Name: COX-2 Inhibitor V, FK3311
Brand: MM

The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Synonim(y):

COX-2 Inhibitor V, FK3311, 4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₅H₁₃F₂NO₄S

Numer CAS:

116686-15-8

Masa cząsteczkowa:

341.33

MDL number:

MFCD00876455

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Właściwości

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

ethanol: 15 mg/mL, DMSO: 30 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1c(ccc(c1)F)Oc2c(ccc(c2)C(=O)C)N[S](=O)(=O)C

InChI

1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3

InChI key

DIIYLGZNZGPXRR-UHFFFAOYSA-N

Opis

General description

A cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC₅₀ = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC₅₀ = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Otani, Y., et al. 2007. J. Invest. Surg.20, 175.
Sunose, Y., et al. 2001. Transplant Proc.33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res.44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull.41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull.40, 2399.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	236005	401482	401481
Sigma-Aldrich 236015 COX-2 Inhibitor V, FK3311	Sigma-Aldrich 236005 COX-1 Inhibitor, FR122047	Sigma-Aldrich 401482 IKK-2 Inhibitor V	Sigma-Aldrich 401481 Inhibitor IKK-2 IV
description The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.	description The COX-1 Inhibitor, FR122047, also referenced under CAS 130717-51-0, controls the biological activity of COX-1. This small molecule/inhibitor is primarily used for Cell Signaling applications.	description The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.	description The IKK-2 Inhibitor IV, also referenced under CAS 507475-17-4, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 30 mg/mL, ethanol: 15 mg/mL	solubility water: 4 mg/mL, DMSO: 5 mg/mL, 1 M HCl: 2 mg/mL	solubility DMSO: 5 mg/mL, ethanol: 1 mg/mL	solubility DMSO: 10 mg/mL

Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 1

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Lot/Batch Number

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