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420128

JNK Inhibitor II

Name: JNK Inhibitor II
Brand: MM

InSolution, ≥98%

Synonim(y):

InSolution JNK Inhibitor II

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₁₄H₈N₂O

Masa cząsteczkowa:

220.23

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

liquid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

Informacje o cenach i dostępności nie są obecnie dostępne.

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Właściwości

Quality Segment

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

yellow-brown

shipped in

wet ice

storage temp.

−20°C

Opis

General description

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.

Biochem/physiol Actions

Target IC₅₀: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3

Primary Target
JNK 1, JNK 2, JNK 3

Product competes with ATP.

Reversible: yes

Cell permeable: yes

Packaging

Packaged under inert gas

Physical form

A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.

Preparation Note

Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.

Other Notes

Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA98, 13681.
Han, Z., et al. 2001. J. Clin. Invest.108, 73.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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Ta pozycja	420119	420136	420116
Sigma-Aldrich 420128 JNK Inhibitor II	Sigma-Aldrich 420119 JNK Inhibitor II	Sigma-Aldrich 420136 JNK Inhibitor IX	Sigma-Aldrich 420116 Inhibitor JNK I, forma (L), przepuszczalna dla komórek
description InSolution, ≥98%	description JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC₅₀ = 40 nM for JNK-1 & JNK-2 & 90 nM for JNK-3).	description The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The JNK Inhibitor I, (L)-Form, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
form liquid	form solid	form solid	form lyophilized solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥97% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
storage condition protect from light, desiccated (hygroscopic), OK to freeze	storage condition OK to freeze, protect from light	storage condition protect from light, OK to freeze	storage condition desiccated (hygroscopic), OK to freeze

Klasa składowania

10 - Combustible liquids

WGK

WGK 2

Temperatura zapłonu (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Temperatura zapłonu (°C)

87 °C - closed cup - (Dimethylsulfoxide)

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