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437650

Lipopolysaccharide

Name: Lipopolysaccharide
Brand: MM

from Salmonella typhimurium, , lyophilized, iNOS stimulator, Calbiochem

Synonim(y):

Salmonella LPS, Salmonella endotoxin

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Informacje o tej pozycji

UNSPSC Code:

12352201

NACRES:

NA.77

Form:

lyophilized

Storage condition:

OK to freeze

Informacje o cenach i dostępności nie są obecnie dostępne.

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Właściwości

Nazwa produktu

Lipopolysaccharide, Salmonella typhimurium, Stimulates the activity of inducible nitric oxide synthase.

description

RTECS - OJ0895637

Quality Segment

100

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

impurities

≤2% nucleic acid, ≤2% protein

solubility

water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Opis

General description

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define revelent pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Inducible nitric oxide synthase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

Other Notes

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Ta pozycja	L2262	L7261	L6511
Sigma-Aldrich 437650 Lipopolysaccharide, Salmonella typhimurium	Sigma-Aldrich L2262 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L7261 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L6511 Lipopolysaccharides from Salmonella enterica serotype typhimurium
description Stimulates the activity of inducible nitric oxide synthase.	description purified by gel-filtration chromatography	description purified by trichloroacetic acid extraction	description purified by phenol extraction
form lyophilized	form lyophilized powder	form lyophilized powder	form lyophilized powder
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition OK to freeze	storage condition -	storage condition -	storage condition -
solubility water: 5 mg/mL	solubility water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow	solubility water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow	solubility water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow

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Piktogramy

GHS06

Słowo ostrzegawcze

Danger

Kody zagrożeń

H300

Ostrzeżenia

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

Klasa składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)