454575

N-Methyl-D-aspartic Acid hydrate

>95% (TLC), solid, excitatory amino acid neurotransmitter, Calbiochem^®

• Synonim(y): N-Methyl-D-aspartic Acid, Hydrate, NMDA
• Wzór empiryczny (zapis Hilla): C₅H₉NO₄ · xH₂O
• Numer CAS: 6384-92-5
• Masa cząsteczkowa: 147.13 (anhydrous basis)
• UNSPSC Code: 12352209
• NACRES: NA.77
• MDL number: MFCD00004226
• Assay: >95% (TLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Nazwa produktu: N-Methyl-D-aspartic Acid, Hydrate, Excitatory amino acid neurotransmitter.
• Quality Segment: 100
• description: Merck USA index - 14, 6662
• assay: >95% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water: 1 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• SMILES string: N([C@H](CC(=O)O)C(=O)[O-])C
• InChI: 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
• InChI key: HOKKHZGPKSLGJE-GSVOUGTGSA-M

Opis

General description

An excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Excitatory amino acid neurotransmitter. Selective agonist of the glutamate receptor that regulates Ca²⁺ channels. Important in long-term potentiation, ischemia, and epilepsy. NMDA receptors are involved in the "fine tuning" of synaptic connections in the developing brain. Chronic treatment with NMDA produces structural changes in synaptic morphology. Over-excitation of NMDA receptors causes neuronal degeneration and cell death.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Glutamate receptor that regulates Ca2+ channels

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for several days at 4°C.

Other Notes

Mattson, M.P., et al. 1993. J. Neurosci. 13, 4575.
Yen, L-H., et al. 1993. J. Neurosci. 13, 4949.
Swann, J.W., et al. 1992. Epilepsy Res. Suppl. 9, 115.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable