472804

S-Methyl-L-thiocitrulline, Dihydrochloride

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

• Synonim(y): S-Methyl-L-thiocitrulline, Dihydrochloride, N ^δ-(S-Methyl)isothioureido-L-ornithine, N^δ-(S-Methyl)isothioureido-L-ornithine
• Wzór empiryczny (zapis Hilla): C₇H₁₅N₃O₂S · 2HCl
• Numer CAS: 209589-59-3
• Masa cząsteczkowa: 278.20
• MDL number: MFCD00270884
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, desiccated (hygroscopic)

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated (hygroscopic)
• color: white to off-white
• solubility: water: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: S(C)\C(=N/CCC[C@H]([N+H3])C(=O)[O-])\N
• InChI: 1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1
• InChI key: NGVMVBQRKZPFLB-YFKPBYRVSA-N

Opis

General description

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

A cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

Biochem/physiol Actions

Reversible: no

Target IC₅₀: 300 nM for rat neuronal nitric oxide synthase

Cell permeable: yes

Primary Target
Rat neuronal nitric oxide synthase

Product does not compete with ATP.

Packaging

Packaged under inert gas

Other Notes

Krishnaswamy, N., et al. 1995. J. Biol. Chem.270, 11103.
Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3