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52332

Phenylmethylsulfonyl Fluoride

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

Synonim(y):

Phenylmethylsulfonyl Fluoride, Benzylsulfonyl Fluoride, PMSF

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Rozmiar/SKUDostępnośćCena netto
1 g

Przewidywany termin wysyłki05 października 2026zKuehne + Nagel Sp. z o.o.

346,00 zł
5 g

Przewidywany termin wysyłki05 października 2026zKuehne + Nagel Sp. z o.o.

611,00 zł
25 g

Przewidywany termin wysyłki05 października 2026zKuehne + Nagel Sp. z o.o.

1800,00 zł

Informacje o tej pozycji

Wzór liniowy:
C6H5CH2SO2F
Numer CAS:
329-98-6
Masa cząsteczkowa:
174.19
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00007424
Assay:
≥99% (GC)
Form:
crystalline solid
Storage condition:
OK to freeze, desiccated

346,00 zł

Przewidywany termin wysyłki05 października 2026Szczegóły

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Quality Segment

description

RTECS - XT8040000

assay

≥99% (GC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated

color

white to off-white

solubility

ethanol: soluble, isopropanol: soluble, methanol: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

F[S](=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI key

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

General description

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).

Biochem/physiol Actions

Cell permeable: no
Primary Target
serine proteases
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
t½ = 1 hour at pH 7.5. Effective concentration: 50 μM.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Seitz, R., et al. 1993. Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Corrosive (L)
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Ta pozycja
7883093482P7626
Phenylmethylsulfonyl Fluoride Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

Sigma-Aldrich

52332

Phenylmethylsulfonyl Fluoride

Phenylmethanesulfonyl fluoride ≥99.0% (T)

Sigma-Aldrich

78830

Phenylmethanesulfonyl fluoride

Phenylmethanesulfonyl fluoride solution ~0.1 M in ethanol (T)

Sigma-Aldrich

93482

Phenylmethanesulfonyl fluoride solution

Phenylmethanesulfonyl fluoride ≥98.5% (GC)

Sigma-Aldrich

P7626

Phenylmethanesulfonyl fluoride

description

Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.

description

≥99.0% (T)

description

~0.1 M in ethanol (T)

description

≥98.5% (GC)

assay

≥99% (GC)

assay

≥99.0% (T)

assay

-

assay

≥98.5% (GC)

form

crystalline solid

form

powder or crystals

form

liquid

form

powder

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

storage temp.

10-30°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

solubility

methanol: soluble, isopropanol: soluble

solubility

anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)

solubility

-

solubility

H2O: unstable, dry solvents (ethanol, methanol, and 2-propanol): 200 mM (Stock solution are stable for months at 4°C.)

Piktogramy

Skull and crossbonesCorrosion
GHS06,GHS05

Słowo ostrzegawcze

Danger

Kody zagrożeń

H301,H314

Hazard Classifications

Acute Tox. 3 Oral - Skin Corr. 1B

Klasa składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

  1. What should it be reconstituted in for best results? You mention the short half life yet long stability when refrigerated.

    1 answer

    1. Phenylmethylsulfonyl Fluoride can be dissolved in either anhydrous isopropanol, ethanol or DMSO at either 100 mM or 200 mM. Aliquot in single use aliquots and store at-20°C for 6 to 9 months. Protect from moisture. The recommended storage temperature and length of storage is from literature references and not from data collected by Millipore Sigma.

      Once the concentrated stock is diluted, prepare in a suitable aqueous buffer and use immediately. Do not refrigerate the working solution for future use.

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