5291

Polymyxin B Sulfate

Polymyxin B Sulfate, CAS 1405-20-5, is an antibiotic that is effective against Gram-positive bacteria. Inhibits phospholipid-sensitive Ca²⁺-dependent protein kinases.

• Synonim(y): Polymyxin B Sulfate, Aerosporin
• Numer CAS: 1405-20-5
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00131991
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Quality Segment: 200
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: water: 25 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI key: HNDFYNOVSOOGDU-UHFFFAOYSA-N

Opis

General description

Polymyxin B is a polypeptide antibacterial that belongs to the polymyxin family. It exerts its effects against Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, Enterobacter sp., and Klebsiella sp.. Polymyxin B sulfate is a mixture of polymyxin B₁ sulfate and polymyxin B₂ sulfate.

Application

Polymyxin B Sulfate - CAS 1405-20-5 – Calbiochem has been used:

• to neutralize the endotoxins in bovine serum albumin
• in the in vitro treatment of hepatic stellate cells (HSCs)
• as an antibiotic in collateral sensitivity and cross-resistance analysis in Escherichia coli

Biochem/physiol Actions

Polymyxin B possesses antiendotoxin activity. It binds to lipid A of the lipopolysaccharide (LPS) molecules and facilitates penetration by displacing Ca²⁺ and Mg²⁺ in the outer membrane of Gram-negative bacteria.

Other Notes

Lucas, M., et al. 1994. Biochem. Pharmacol. 47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, S.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Filkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable