SCC186

DOV13 Human Ovarian Carcinoma Cell Line

The DOV13 human ovarian carcinoma cell line is a highly characterized model for metastatic ovarian cancer studies.

• NACRES: NA.28
• UNSPSC Code: 41106514

Właściwości

• application(s): cell analysis

Opis

General description

The DOV13 human ovarian carcinoma cell line is one of the most studied and characterized cellular models for metastatic ovarian cancers, having been utilized in many cellular studies focusing on cellular migration and invasion. DOV13 cells are responsive to vascular endothelial growth factor (VEGF) (2), express estrogen receptor (3) and matrilysin (MMP-7), a marker of metastatic and invasive epithelial carcinomas (4), and secrete the proteolytic factor matrix metalloproteinase-2 (MMP-2) (5). DOV13 cells are genetically well-characterized and harbor deletion of the tumor suppressor CDKN2A (6). The characteristics of the DOV13 cell line make it a pertinent model for the most malignant ovarian cancer.

Epithelial carcinomas are the most common ovarian cancer, accounting for 90 percent of cases. Ovarian carcinoma is typically diagnosed at late stage after cancer has metastasized beyond the ovaries, greatly reducing treatment options and contributing to the poor survival rate of this cancer type (1). Robust cellular models have been essential to understanding the mechanisms of ovarian cancer metastasis and development of potential therapeutic strategies.

Source:
The DOV13 human ovarian carcinoma cell line was isolated from ovarian adenocarcinoma tissue (2).

Research Category:
Cancer

Biochem/physiol Actions

Human, Cancer Cells

Packaging

≥1X10⁶ cells/vial

Preparation Note

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact licensing@milliporesigma.com.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable