No validated stability data are available for this product in dimethyl sulfoxide solution stored at -20 °C. This product is soluble in dimethyl sulfoxide, and literature reports use at 250 nM. Prepare single-use aliquots, store at -20 °C protected from light, and avoid repeated freeze–thaw cycles. For applications requiring strict stability control, prepare the solution immediately before use.
SCT057
BioTracker ERthermAC Temperature-Sensitive Live Cell Dye
Synonim(y):
Live cell imaging probe
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 mg | Przewidywany termin wysyłki16 listopada 2026zKuehne + Nagel Sp. z o.o. | 1780,00 zł |
Informacje o tej pozycji
NACRES:
NA.32
UNSPSC Code:
12171501
1780,00 zł
Przewidywany termin wysyłki16 listopada 2026Szczegóły
Pomoc techniczna
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Pozwól nam pomóctechnique(s)
cell based assay: suitable
General description
Brown adipocyte tissue (BAT) has been shown to be present in human newborns, small infants, as well as adults. Stimulation of BAT energy expenditure is considered a potential new drug target for obesity and diabetes treatments, and there is increasing interest in the discovery of novel mechanisms and substances for this purpose. However, to facilitate the development of breakthrough therapies, it is essential that techniques to measure the signature function of BAT are readily available.
The BioTracker™ ERthermAC thermosensitive live cell dye is a novel BODIPY-based dye that is capable of imaging heat production in individual brown adipocytes. The dye′s features such as small size, excellent cellular uptake, low cytotoxicity and robust photostability make it very biocompatible. Data obtained using this dye is comparable with that obtained by conventional methods measuring mitochondrial depolarization, oxygen consumption, and extracellular acidification rates, and with thermal power measurements obtained using the calScreener.
Spectral Properties:
References:
Kriszt R et al. Optical visualization of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep. 2017 May 3;7(1):1383.
The BioTracker™ ERthermAC thermosensitive live cell dye is a novel BODIPY-based dye that is capable of imaging heat production in individual brown adipocytes. The dye′s features such as small size, excellent cellular uptake, low cytotoxicity and robust photostability make it very biocompatible. Data obtained using this dye is comparable with that obtained by conventional methods measuring mitochondrial depolarization, oxygen consumption, and extracellular acidification rates, and with thermal power measurements obtained using the calScreener.
Spectral Properties:
- Absorption: 565 nm
- Emissions: 590 nm (Orange/Red) in polarized mitochondria
- Emissions: 527 nm (Green) in depolarized mitochondria
References:
Kriszt R et al. Optical visualization of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep. 2017 May 3;7(1):1383.
Application
Application: Live cell fluorescent imaging
Live cell imaging thermosensitive dye to visualize heat production in brown adipocytes.
Analysis Note
Purity: ≥98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 541.28 g/mol
Molar Mass: 541.28 g/mol
Other Notes
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
Legal Information
BioTracker is a trademark of Merck KGaA, Darmstadt, Germany
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Ta pozycja | |||
|---|---|---|---|
| description - | description Live cell imaging dye for cellular adenosine triphosphate (ATP) localized to mitochondria used to detect metabolic activity, cell proliferation and overall cell health. | description Live cell imaging dye for hypochlorus acid (HOCL) used to detect phagocytosis, inflammation and cellular apoptosis. | description Live cell imaging dye for hypochlorous acid (HOCl) targeted to cellular lysosomes used to detect phagocytosis, inflammation and cellular apoptosis. |
| technique(s) cell based assay: suitable | technique(s) live cell imaging : suitable, cell based assay: suitable | technique(s) live cell imaging : suitable, cell based assay: suitable | technique(s) cell based assay: suitable, live cell imaging : suitable |
Klasa składowania
13 - Non Combustible Solids
Co się dzieje?
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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What's the stability of the drug once resuspended in DMSO and stored in -20 degrees?
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What solvent is used to resuspend this dye please?
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This product is soluble in DMSO, and literature reports its usage at a 250 nM concentration. A solution can be made accordingly, and a more concentrated stock is possible. The product should be aliquoted and stored appropriately. Store BioTracker ERthermAC Temperature-sensitive Live Cell Dye at -20°C, desiccate, and protect from light.
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