27285

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

• Synonym(s): Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na₂, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na₂
• Empirical Formula (Hill Notation): C₁₀H₁₄N₂Na₂O₈ · 2H₂O
• CAS Number: 6381-92-6
• Molecular Weight: 372.24
• Beilstein: 3900609
• Numer EC: 205-358-3
• Identyfikator substancji w PubChem: 24856480
• NACRES: NA.77

Properties

• Agency: tested according to BP; tested according to Ph. Eur.; tested according to USP
• Poziom jakości: 200
• reg. compliance: tested according to FCC
• Próba: 99.0-101.0%
• forma: crystals
• jakość: meets analytical specification of Ph. Eur., BP, USP, FCC
• reaction suitability: reagent type: chelator
• zanieczyszczenia: residual solvents, complies; ≤0.001% cyanide (CN); ≤0.001% heavy metals (as Pb); ≤0.1% nitrilotriacetic acid (HPLC) (HPLC)
• strata: 8.7-11.4% loss on drying, 200 °C, 3 h
• pH: 4-5 (20 °C, 5%)
• mp: 248 °C (dec.) (lit.)
• rozpuszczalność: water: soluble 100 g/L at 20 °C
• ślady anionów: chloride (Cl^-): ≤100 mg/kg; sulfate (SO₄^2-): ≤500 mg/kg
• ślady kationów: As: ≤1 mg/kg; Ca:, in accordance; Fe: ≤10 mg/kg; Pb: ≤10 mg/kg
• application(s): pharmaceutical (small molecule)
• SMILES string: O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O
• InChI: 1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2
• InChI key: OVBJJZOQPCKUOR-UHFFFAOYSA-L

Description

Zastosowanie

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na₂HPO4 and citric acid for preparing Na₂EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production

Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Działania biochem./fizjol.

Ethylenediaminetetraacetic acid disodium salt dihydrate is a widely used chelator of divalent cations like Ca⁺² and inhibits metal ion-dependent proteases such as calcium-dependent cysteine proteases. EDTA also acts as a chelator of the zinc ion in the active site of metalloproteases; thus it inhibits metalloproteases that requires zinc for activity. Additionally, EDTA prevents platelet aggregation and is a preferred anticoagulant for platelet counts.

Safety Information

• piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H332 - H373
• Zwroty wskazujące środki ostrożności: P260 - P271 - P304 + P340 + P312 - P314 - P501
• Klasyfikacja zagrożeń: Acute Tox. 4 Inhalation - STOT RE 2 Inhalation
• Organy docelowe: Respiratory Tract
• Kod klasy składowania: 11 - Combustible Solids
• WGK: WGK 2
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)