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A9518

Ampicillin sodium salt

Ampicillin sodium salt

Synonim(y):

D-(−)-α-Aminobenzylpenicillin sodium salt

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Wybierz wielkość

5 G

414,00 zł

25 G

1430,00 zł

100 G

4850,00 zł

414,00 zł

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C16H18N3NaO4S
Numer CAS:
69-52-3
Masa cząsteczkowa:
371.39
Beilstein:
4119211
Numer WE:
200-708-1
Numer MDL:
MFCD00064313
Kod UNSPSC:
12352107
Identyfikator substancji w PubChem:
24891463
NACRES:
NA.76

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Pozwól nam pomóc

pochodzenie biologiczne

synthetic (chemical)

Poziom jakości

200

Formularz

powder

kolor

white to off-white

mp

215 °C (dec.) (lit.)

rozpuszczalność

water: 50 g/L

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria

Zastosowanie

agriculture

Tryb działania

cell wall synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

Klucz InChI

KLOHDWPABZXLGI-YWUHCJSESA-M

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Ta pozycja
A0166A8351PHR1424
Ampicillin sodium salt

Sigma-Aldrich

A9518

Ampicillin sodium salt

Ampicillin sodium salt powder or crystals, BioReagent, suitable for cell culture

Sigma-Aldrich

A0166

Ampicillin sodium salt

Ampicillin sodium salt BioXtra, suitable for cell culture

Sigma-Aldrich

A8351

Ampicillin sodium salt

Ampicillin Sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1424

Ampicillin Sodium

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes

mode of action

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

application(s)

agriculture

application(s)

-

application(s)

-

application(s)

pharmaceutical (small molecule)

form

powder

form

powder or crystals

form

powder

form

-

biological source

synthetic (chemical)

biological source

synthetic

biological source

-

biological source

-

Opis ogólny

Ampicillin sodium salt is a member of the extended-spectrum β-lactam family and a semisynthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall. Ampicillin sodium salt is active against a wide range of Gram-positive and Gram-negative bacteria, including E. coli, β-lactam-sensitive VRE, vancomycin-resistant Enterococcus species, Staphylococcus aureus, and Streptococcus pneumoniae. It is commonly used in research laboratories to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, and the selection and maintenance of recombinant plasmids in E. coli.

Zastosowanie

Ampicillin sodium salt has been used:
  • to select for ampicillin resistance in mutated and transformed cells

Działania biochem./fizjol.

Mode of Action: This is a ß-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Mode of Resistance: Administration with ß-lactamase cleaves the ß-lactam ring of Ampicillin and inactivates it.

Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Cechy i korzyści

  • High-quality antibiotic suitable for multiple research applications
  • Ideal for Cell Biology and Biochemical research.

Uwaga dotycząca przygotowania

Szczelnie zamknięte. Suche. Przechowywać pod zamknięciem lub w miejscu dostępnym wyłącznie dla wykwalifikowanych lub upoważnionych osób.
Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

Inne uwagi

For additional information on our range of Biochemicals, please complete this form.
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

Oświadczenie o zrzeczeniu się odpowiedzialności

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.
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Numer produktu
Opis
Cennik

08168

Timestrip ™ 8 °C

Piktogramy

Health hazard
GHS08

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H317,H334

Zwroty wskazujące środki ostrożności

P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313

Klasyfikacja zagrożeń

Resp. Sens. 1A - Skin Sens. 1A

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
0000485083
0000485083
0000483792
0000483792
0000462287

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Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Christoffer V Sørensen et al.
Toxins, 12(4) (2020-04-15)
Antibiotics are often administered with antivenom following snakebite envenomings in order to avoid secondary bacterial infections. However, to this date, no studies have evaluated whether antibiotics may have undesirable potentiating effects on snake venom. Herein, we demonstrate that four commonly
Bram Lories et al.
Current biology : CB, 30(7), 1231-1244 (2020-02-23)
Bacteria use complex regulatory networks to cope with stress, but the function of these networks in natural habitats is poorly understood. The competition sensing hypothesis states that bacterial stress response systems can serve to detect ecological competition, but studying regulatory
Melanie E Mendez et al.
International journal of molecular sciences, 21(17) (2020-09-10)
Osteoarthritis (OA) is a painful and debilitating disease characterized by the chronic and progressive degradation of articular cartilage. Post-traumatic OA (PTOA) is a secondary form of OA that develops in ~50% of cases of severe articular injury. Inflammation and re-occurring
Nuria Fernández-Hidalgo et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 56(9), 1261-1268 (2013-02-09)
The aim of this study was to compare the effectiveness of the ampicillin plus ceftriaxone (AC) and ampicillin plus gentamicin (AG) combinations for treating Enterococcus faecalis infective endocarditis (EFIE). An observational, nonrandomized, comparative multicenter cohort study was conducted at 17
Eric S Luth et al.
PLoS genetics, 17(2), e1009375-e1009375 (2021-02-10)
Several intracellular trafficking pathways contribute to the regulation of AMPA receptor (AMPAR) levels at synapses and the control of synaptic strength. While much has been learned about these intracellular trafficking pathways, a major challenge is to understand how extracellular factors
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Overview on how to maintain proper cell culture laboratory safety including steps on performing lab risk assessments, surface disinfection, biohazard and waste removal. Free ECACC handbook download.

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Questions

1–7 of 7 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. We purchased Ampicillin sodium salt (loc #BCBL4878V) back in 2014. This has been stored as a powder in the fridge since we purchased it. Is there an expiration for the powder?

    1 answer

    1. This product is assigned an expiration date of approximately of one year from the date of quality release. To assure optimum potency, it would be best to purchase new material.

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  4. What is the solubility of Product A9518, Ampicillin sodium salt?

    1 answer

    1. This product is soluble in water at a concentration of 50 mg/mL, producing a clear, colorless to faint yellow solution.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  6. Is Ampicillin product stable in solution?

    1 answer

    1. We recommend using freshly prepared solutions. A concentrated solution of sodium ampicillin in water (approximately 330 mg/mL) may be expected to lose about 10% potency in 20 hours at -20°C.

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  7. How do I use Ampicllin in agar plates?

    1 answer

    1. For plates, add ampicillin to autoclaved media cooled to 48°C, to a final concentration of 35-50 μg/mL. Pour the plates, and allow them to cool completely. Plates may be stored at 2-8°C for up to only 1-2 weeks before use.

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