D8809

Daunorubicin hydrochloride

meets USP testing specifications

• Synonym(s): Daunomycin hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₀ · HCl
• CAS Number: 23541-50-6
• Molecular Weight: 563.98
• Beilstein: 4229221
• Numer EC: 245-723-4
• Numer MDL: MFCD04974507
• Identyfikator substancji w PubChem: 24894229
• NACRES: NA.21

Properties

• Agency: USP/NF; meets USP testing specifications
• Poziom jakości: 200
• forma: solid
• spektrum działania antybiotyku: neoplastics
• Tryb działania: DNA synthesis | interferes
• temp. przechowywania: 2-8°C
• SMILES string: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
• InChI: 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
• InChI key: GUGHGUXZJWAIAS-QQYBVWGSSA-N
• Gene Information: human ... TOP2A(7153)

Description

Opakowanie

1, 10 mg in glass bottle

50 mg in poly bottle

Działania biochem./fizjol.

Naturally fluorescent anthracycline antibiotic, anticancer drug. Substrate for Pgp, MRP-1 and BCRP. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes. Daunorubicin is sequestered into lysosomes according to a pH partitioning type mechanism. Strong inhibitor of DNA and RNA synthesis.

Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Safety Information

• piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301 - H341 - H351 - H360FD
• Zwroty wskazujące środki ostrożności: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• Kod klasy składowania: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges