S6501

Streptomycin sulfate salt

powder

• Synonim(y): 2-[(1S,2R,3R,4S,5R,6R)-5-(diaminomethylideneamino)-2-[(2R,3S,4S,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyl-oxolan-2-yl]oxy-3,4,6-trihydroxy-cyclohexyl]guanidine
• Wzór liniowy: C₂₁H₃₉N₇O₁₂ · 1.5 H₂SO₄
• Numer CAS: 3810-74-0
• Masa cząsteczkowa: 728.69
• Beilstein: 3894995
• Numer EC: 223-286-0
• Numer MDL: MFCD00037023
• Identyfikator substancji w PubChem: 24899705
• NACRES: NA.76

Właściwości

• pochodzenie biologiczne: Streptomyces griseus
• Poziom jakości: 200
• forma: powder
• siła działania: ≥720 I.U. per mg
• masa cząsteczkowa: calculated mol wt 1457.38 ((C₂₁H₃₉N₇O₁₂)₂ ⋅3H₂O₄S)
• warunki przechowywania: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• kolor: white to off-white
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Tryb działania: protein synthesis | interferes
• temp. przechowywania: 2-8°C
• SMILES string: OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N
• InChI: 1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
• InChI key: QTENRWWVYAAPBI-YZTFXSNBSA-N

Opis

Opis ogólny

Chemical structure: aminoglycoside

Zastosowanie

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Działania biochem./fizjol.

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Przestroga

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Uwaga dotycząca przygotowania

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Informacja o środkach bezpieczeństwa

• piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302 - H361fd
• Zwroty wskazujące środki ostrożności: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Repr. 2
• Kod klasy składowania: 11 - Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves