Merck
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S6501

Sigma-Aldrich

Streptomycin sulfate salt

powder

Linear Formula:
C21H39N7O12 · 1.5 H2SO4
CAS Number:
Molecular Weight:
728.69
Beilstein:
3894995
Numer EC:
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.76

pochodzenie biologiczne

Streptomyces griseus

Poziom jakości

200

forma

powder

siła działania

≥720 I.U. per mg

masa cząsteczkowa

calculated mol wt 1457.38 ((C21H39N7O12)2 ⋅3H2O4S)

warunki przechowywania

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

kolor

white to off-white

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Tryb działania

protein synthesis | interferes

temp. przechowywania

2-8°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1

InChI key

QTENRWWVYAAPBI-YZTFXSNBSA-N

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Related Categories

Opis ogólny

Chemical structure: aminoglycoside

Opakowanie

5, 25, 50, 100 g in poly bottle
1 kg in poly bottle

Zastosowanie

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Działania biochem./fizjol.

Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation.

Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin.

Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria.

Przestroga

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Uwaga dotycząca przygotowania

Stock solutions should be prepared directly in the vial with sterile water at concentrations between 20-25 mg/mL.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

piktogramy

Exclamation markHealth hazard

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

Zwroty wskazujące środki ostrożności

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Repr. 2

Kod klasy składowania

11 - Combustible Solids

WGK

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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