282200

Galangin

autophagy inducing flavonoid

• Synonim(y): 3,5,7-Trihydroxyflavone, Norizalpinin
• Wzór empiryczny (zapis Hilla): C₁₅H₁₀O₅
• Numer CAS: 548-83-4
• Masa cząsteczkowa: 270.24
• UNSPSC Code: 41116107
• NACRES: NA.79
• PubChem Substance ID: 57648294
• EC Number: 208-960-4
• Beilstein/REAXYS Number: 272179
• MDL number: MFCD00006833

Właściwości

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: yellow
• mp: 214-215 °C (lit.)
• SMILES string: Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
• InChI key: VCCRNZQBSJXYJD-UHFFFAOYSA-N
• Gene Information: human ... ADORA2A(135), ADORA3(140), CYP1A2(1544) ; rat ... Adora1(29290), Adora2a(25369)

Opis

General description

Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.

Application

Galangin has been used:

• as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
• to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
• as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy

Biochem/physiol Actions

Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves