Merck
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30450

Sigma-Aldrich

Daunorubicin hydrochloride

≥90% (HPLC)

Synonym(s):
Daunomycin hydrochloride
Empirical Formula (Hill Notation):
C27H29NO10 · HCl
CAS Number:
Molecular Weight:
563.98
Beilstein:
4229221
Numer EC:
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.85

pochodzenie biologiczne

synthetic

Poziom jakości

200

próba

≥90% (HPLC)

forma

powder

kolor

red to deep red

spektrum działania antybiotyku

neoplastics

Tryb działania

DNA synthesis | interferes

temp. przechowywania

2-8°C

SMILES string

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI key

GUGHGUXZJWAIAS-QQYBVWGSSA-N

Gene Information

human ... TOP2A(7153)

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Opis ogólny

Chemical structure: aminoglycoside

Zastosowanie

Daunorubicin hydrochloride is used in photostability[1], antileukemic[2], and drug metabolism studies[3].

Działania biochem./fizjol.

On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.

Opakowanie

5 mg, 25 mg

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.

piktogramy

Skull and crossbonesHealth hazard

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Zwroty wskazujące środki ostrożności

Klasyfikacja zagrożeń

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

Kod klasy składowania

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificate of Analysis

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Certificate of Origin

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