Solubility is not tested internally, but this product should be sparingly soluble in 1:1 ethanol:water. The addition of small amounts of acetic acid may aid in dissolving this product. Greater solubility is expected in warm methanol at the listed concentration of 10 mM, or approximately 3.8 mg/mL. Minimal solubility is also observed in 0.3 M NaOH, up to about 4 mg/mL.
Przejdź do
73914
Sphingosine 1-phosphate
≥98.0% (TLC)
Synonim(y):
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1400,00 zł |
5 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 5270,00 zł 4479,50 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C18H38NO5P
Numer CAS:
Masa cząsteczkowa:
379.47
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Assay:
≥98.0% (TLC)
Form:
powder
1400,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócQuality Segment
assay
≥98.0% (TLC)
form
powder
composition
carbon content, 56.97% , hydrogen content, 10.09% , nitrogen content, 3.69%
lipid type
sphingolipids
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
InChI
1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChI key
DUYSYHSSBDVJSM-KRWOKUGFSA-N
Application
Repurposing Siponimod for osteoporosis: A study highlighted the potential of Siponimod, an S1P receptor modulator originally developed for multiple sclerosis, to treat osteoporosis by influencing Sphingosine 1-phosphate pathways (Hu et al., 2024).
Sphingosine-1-phosphate in ocular health: Research demonstrated that a selective agonist for Sphingosine-1-phosphate receptor 1/5 could mitigate ocular vascular pathologies, suggesting therapeutic potentials in eye disease management, it is also responsible for regulating various intracellular processes, including cell survival, differentiation, and proliferation (Nakamura et al., 2024).
Targeting diabetic kidney disease: The study investigated how Plantaginis Semen, through the sphingosine kinase 1/Sphingosine-1-phosphate pathway, could ameliorate diabetic kidney disease, underscoring the pathways role in metabolic health (Lan et al., 2024).
Advancements in neurodegenerative disease treatments: A review focused on the development of small-molecule modulators targeting Sphingosine-1-phosphate receptors, presenting new directions in treating neurodegenerative diseases (Sankar Kar et al., 2024).
Sphingosine-1-phosphate in ocular health: Research demonstrated that a selective agonist for Sphingosine-1-phosphate receptor 1/5 could mitigate ocular vascular pathologies, suggesting therapeutic potentials in eye disease management, it is also responsible for regulating various intracellular processes, including cell survival, differentiation, and proliferation (Nakamura et al., 2024).
Targeting diabetic kidney disease: The study investigated how Plantaginis Semen, through the sphingosine kinase 1/Sphingosine-1-phosphate pathway, could ameliorate diabetic kidney disease, underscoring the pathways role in metabolic health (Lan et al., 2024).
Advancements in neurodegenerative disease treatments: A review focused on the development of small-molecule modulators targeting Sphingosine-1-phosphate receptors, presenting new directions in treating neurodegenerative diseases (Sankar Kar et al., 2024).
Biochem/physiol Actions
A lipid second messenger that binds to S1P1 and S1P3 receptors. Mobilizes intracellular Ca2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Ta pozycja | |||
|---|---|---|---|
| description ≥98.0% (TLC) | description ≥95%, powder | description Avanti Research™ - A Croda Brand | description A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. |
| assay ≥98.0% (TLC) | assay ≥95% | assay >99% (TLC) | assay ≥95% (elemental analysis) |
| form powder | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| composition carbon content, 56.97% , nitrogen content, 3.69% , hydrogen content, 10.09% | composition - | composition - | composition - |
| lipid type sphingolipids | lipid type - | lipid type sphingolipids | lipid type - |
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Klasa składowania
11 - Combustible Solids
WGK
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Hello Sir, I have received Sphingosine-1-phosphate (catalog #73914) and attempted to dissolve it, but I couldn't find the recommended solvent. Could you please let me know which solvent should be used to prepare a 10 mM stock? Thanks.
1 answer-
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