78830

Phenylmethanesulfonyl fluoride

≥99.0% (T)

• Synonim(y): α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride
• Wzór empiryczny (zapis Hilla): C₇H₇FO₂S
• Numer CAS: 329-98-6
• Masa cząsteczkowa: 174.19
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 57652759
• EC Number: 206-350-2
• Beilstein/REAXYS Number: 2088311
• MDL number: MFCD00007424

Właściwości

• biological source: synthetic
• Quality Segment: 200
• assay: ≥99.0% (T)
• form: powder or crystals
• impurities: ≤0.2% water
• input: general use sample(s)
• mp: 92-95 °C
• solubility: anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)
• storage temp.: room temp
• SMILES string: FS(=O)(=O)Cc1ccccc1
• InChI: 1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
• InChI key: YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Opis

Application

Phenylmethanesulfonyl fluoride has been used as a component in radioimmunoprecipitation buffer for western blot analysis. It has also been used as a component in the RAW264.7 cell lysis buffer for western blotting.

Biochem/physiol Actions

Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice.

Other Notes

Specific trypsin and chymotrypsin inhibitor. Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.

Specific trypsin and chymotrypsin inhibitor; Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS05
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H314
• Ostrzeżenia: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Acute Tox. 3 Oral - Skin Corr. 1B
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges