78830

Sigma-Aldrich

Phenylmethanesulfonyl fluoride

≥99.0% (T)

Synonim(y):
α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, Phenylmethylsulfonyl fluoride, PMSF
Empirical Formula (Hill Notation):
C7H7FO2S
Numer CAS:
Masa cząsteczkowa:
174.19
Beilstein/REAXYS Number:
2088311
Numer EC:
Numer MDL:
Identyfikator substancji w PubChem:
NACRES:
NA.77

Poziom jakości

200

pochodzenie biologiczne

synthetic

próba

≥99.0% (T)

formularz

powder or crystals

zanieczyszczenia

≤0.1% water

mp

92-95 °C

rozpuszczalność

anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)

temp. przechowywania

room temp

SMILES string

FS(=O)(=O)Cc1ccccc1

InChI

1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2

InChI key

YBYRMVIVWMBXKQ-UHFFFAOYSA-N

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Zastosowanie

Phenylmethanesulfonyl fluoride has been used as a component in radioimmunoprecipitation buffer for western blot analysis. It has also been used as a component in the RAW264.7 cell lysis buffer for western blotting.

Działania biochem./fizjol.

Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice.

Inne uwagi

Specific trypsin and chymotrypsin inhibitor. Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.
Specific trypsin and chymotrypsin inhibitor; Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.

piktogramy

CorrosionSkull and crossbones

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

hazcat

Acute Tox. 3 Oral - Skin Corr. 1B

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 3

Temperatura zapłonu °F

Not applicable

Temperatura zapłonu °C

Not applicable

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

Certyfikat analizy

Świadectwo pochodzenia

Quercetin protects RAW264. 7 macrophages from glucosamine-induced apoptosis and lipid accumulation via the endoplasmic reticulum stress pathway
Cai X, et al.
Molecular Medicine Reports, 12(5), 7545-7553 (2015)
Cellular bioenergetics changes in magnocellular neurons may affect copeptin expression in the late phase of sepsis
Oliveira-Pelegrin G R, et al.
Journal of Neuroimmunology, 267(1-2), 28-34 (2014)
Phenylmethanesulfonyl fluoride pretreatment stabilizes plasma lipidome in lipidomic and metabolomic analysis
Wang X, et al.
Analytica Chimica Acta, 893, 77-83 (2015)
beta-catenin dosage is a critical determinant of tracheal basal cell fate determination
Brechbuhl H M, et al.
The American Journal of Pathology, 179(1), 367-379 (2011)
Q S Wang et al.
Acta pharmacologica Sinica, 22(3), 249-252 (2001-12-18)
To study the effect of phenylmethylsulfonyl fluoride (PMSF), a phospholipase C inhibitor, on ischemic injury to brain mitochondria in rats. The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria were measured. The effect of phenylmethylsulfonyl fluoride was...

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