A0606

Aurothioglucose hydrate

≥96% (titration), PKCι-Par6 interaction inhibitor, powder

• Synonim(y): Gold thioglucose, Solganal, Solganol
• Wzór empiryczny (zapis Hilla): C₆H₁₁AuO₅S · xH₂O
• Numer CAS: 12192-57-3
• Masa cząsteczkowa: 392.18 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724383
• NACRES: NA.77
• EC Number: 235-365-7
• Assay: ≥96% (titration)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: Aurothioglucose hydrate, ≥96% (titration)
• Quality Segment: 100
• assay: ≥96% (titration)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1
• InChI key: SGVIEHTYEMEDRR-PKXGBZFFSA-M

Opis

Application

Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.

Biochem/physiol Actions

Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC₅₀ approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.

Potent PKCι-Par6 interaction inhibitor

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves