Pramipexole dihydrochloride (A1237) is described with the synonym (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride, indicating it is the S (L) enantiomer. The optical rotation is measured and can be found in the Certificate of Analysis (COA) for this product. The specification for this product is between -60° and -70°, which is consistent with the S (L) enantiomer of pramipexole.
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A1237
Pramipexole dihydrochloride
>98% (HPLC), Dopamine D2 and D3 receptor agonist, powder
Synonim(y):
(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride, PPX dihydrochloride
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 10 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 406,00 zł | |
| 50 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1710,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C10H17N3S · 2HCl
Numer CAS:
Masa cząsteczkowa:
284.25
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
406,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Pramipexole dihydrochloride, >98% (HPLC), powder
Quality Level
assay
>98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
H2O: >20 mg/mL
originator
Boehringer Ingelheim
storage temp.
2-8°C
SMILES string
Cl.Cl.CCCN[C@H]1CCc2nc(N)sc2C1
InChI
1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
InChI key
QMNWXHSYPXQFSK-KLXURFKVSA-N
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815)
General description
Pramipexole belongs to non-ergoline class and is derived from benzothiazole. It has strong affinity for D2 and D3 receptors (dopamine receptors) compared to other ergoline-derived drugs. However, it does not associate with non-dopamine receptors, for instance adrenergic and serotonin receptors.
Application
Pramipexole dihydrochloride has been used as D2 receptor agonist in dopamine (DA)-depleted striatum slices.[1]
Biochem/physiol Actions
Pramipexole dihydrochloride monohydrate is a dopamine agonist active at D3 and D2 receptor subtypes.
Pramipexole elicits neuroprotective role and may help in treating depression.[4] It also has a potential to modulate limb movement and may be effective in treating restless legs syndrome.[5]
Pramipexole is a dopamine agonist active at D3 and D2 receptor subtypes. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Pramipexole is a therapeutic agent for Parkinson′s disease and restless leg syndrome. It also exhibits antidepressant responses in patients suffering from MDD (major depressive disorder) and bipolar depression.[6]
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Ta pozycja | |||
|---|---|---|---|
| form powder | form - | form powder | form powder |
| assay >98% (HPLC) | assay - | assay - | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 300 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition - | storage condition - | storage condition desiccated |
| solubility H2O: >20 mg/mL | solubility - | solubility alcohol: 20 mg/mL, H2O: soluble | solubility H2O: 20 mg/mL, clear |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 3
target_organs
Central nervous system
Klasa składowania
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Doble M
Drug Design null
Clinical Experience With High-Dosage Pramipexole in Patients With Treatment-Resistant Depressive Episodes in Unipolar and Bipolar Depression.
Jan Fawcett et al.
The American journal of psychiatry, 173(2), 107-111 (2016-02-06)
Esther Lara-González et al.
Neuroscience, 410, 76-96 (2019-05-13)
Parkinson's disease (PD) is a neurodegenerative illness presenting motor and non-motor symptoms due to the loss of dopaminergic terminals in basal ganglia, most importantly, the striatum. L-DOPA relieves many motor signs. Unfortunately, in the long term, L-DOPA use causes motor
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| A1237-50MG | 04061835257768 |
| A1237-10MG | 04061835257751 |
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Is this pramipexole the pure L enantiomer? Or a racemic mixture of L and R? If pure enantiomer: 1. how was this determined and 2. are the data supporting this available?
1 answer-
Helpful?
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