The difference between the Type I and Type II Asialofetuin products does not represent any kind of biochemical or functional difference. These indicate different methods of production and purification. The Type II option, product A1908, utilizes neuraminadase in an enzymatic cleavage step. The Type I, product A4781, utilizes a proprietary modification of that described in Spiro, R.G., J. Biol. Chem., 235, 2860 (1960).
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A1908
Asialofetuin from fetal calf serum
Type II (Sigma designation)
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
50 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 3180,00 zł |
Informacje o tej pozycji
Form:
powder
Biological source:
bovine
3180,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
bovine
Quality Segment
type
Type II (Sigma designation)
form
powder
technique(s)
activity assay: suitable, inhibition assay: suitable
impurities
salt, essentially free, ≤1.0% N-acetylneuraminic acid
solubility
H2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow
storage temp.
2-8°C
Application
Asialofetuin from fetal calf serum is suitable for use:
Incorporation of asialofetuin (AF) in liposomes strongly enhance delivery to and endocytosis by cells displaying the AF receptor, notably hepatocytes. This provides a very efficient route for gene therapy.
Biochem/physiol Actions
Feutins are glycoproteins that belong to the cystatin superfamily. They are characterized by the presence of two tandemly arranged cystatin-like domains and an unrelated domain. It binds to transforming growth factor (TGF)-β/BMP (bone morphogenic protein) cytokines.
Asialofetuin (AF) binds to asialoglycoprotein receptor (ASGP-R) and is employed as a ligand for drug delivery to the hepatocytes. It aids serum-resistant lipoplexes for efficient gene deliver into the HepG2 (human hepatoblastoma) cells.
Preparation Note
Enzymatic cleavage using neuraminidase
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Ta pozycja | |||
|---|---|---|---|
| description Type II (Sigma designation) | description Type I (Sigma designation) | description lyophilized powder, suitable for cell culture | description lyophilized powder |
| biological source bovine | biological source bovine (calf) serum | biological source bovine serum (fetal) | biological source bovine serum (fetal) |
| technique(s) activity assay: suitable, inhibition assay: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, MALDI-MS: suitable |
| form powder | form powder | form lyophilized powder | form lyophilized powder |
| solubility H2O: soluble 1.0 mg/mL, clear to hazy, colorless to very faintly yellow | solubility 0.85% sodium chloride: soluble 1 mg/mL | solubility H2O: 1 mg/mL, colorless to faint yellow or tan | solubility - |
| impurities ≤1.0% N-acetylneuraminic acid, salt, essentially free | impurities salt, essentially free, ≤0.5% N-acetylneuraminic acid | impurities ≤0.3% free N-acetylneuraminic acid | impurities ~0.2% free N-acetylneuraminic acid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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What is the difference in Type 1 versus Type II asialofetuin?
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