A5585

5-(N-Methyl-N-isobutyl)­amiloride

≥98% (TLC), powder

• Synonim(y): MIA
• Wzór empiryczny (zapis Hilla): C₁₁H₁₈ClN₇O
• Numer CAS: 96861-65-3
• Masa cząsteczkowa: 299.76
• NACRES: NA.77
• PubChem Substance ID: 24278228
• UNSPSC Code: 12352200
• MDL number: MFCD00078567
• Assay: ≥98% (TLC)
• Form: powder

Właściwości

• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 200-201 °C
• solubility: methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow
• storage temp.: 2-8°C
• SMILES string: CC(C)CN(C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
• InChI: 1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
• InChI key: RVIUMPLAOXSSGN-UHFFFAOYSA-N
• Gene Information: human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340) ; mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) ; rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Opis

Application

5-(N-Methyl-N-isobutyl)­amiloride is a potent blocker of the Na²/H⁺ antiport. 5-(N-Methyl-N-isobutyl)­amiloride has been used to study early cellular response to acidosis.

Biochem/physiol Actions

Potent blocker of the Na⁺/H⁺ antiport. Possible antitumor agent.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves