A7015

N-(2-Fluorenyl)acetamide

≥98% (HPLC)

• Synonim(y): 2-AAF, 2-Acetamidofluorene, N-Acetyl-2-aminofluorene
• Wzór empiryczny (zapis Hilla): C₁₅H₁₃NO
• Numer CAS: 53-96-3
• Masa cząsteczkowa: 223.27
• UNSPSC Code: 12352103
• NACRES: NA.25
• PubChem Substance ID: 24891166
• EC Number: 200-188-6
• Beilstein/REAXYS Number: 2807677
• MDL number: MFCD00001116

Właściwości

• assay: ≥98% (HPLC)
• form: powder
• mp: 192-196 °C (lit.)
• SMILES string: CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1
• InChI: 1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
• InChI key: CZIHNRWJTSTCEX-UHFFFAOYSA-N

Opis

Application

N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.

Biochem/physiol Actions

A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H350
• pcodes: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges