A9501

Adenosine 3′,5′-cyclic monophosphate

≥98.5% (HPLC), powder

• Synonim(y): 3′,5′-Cyclic AMP, cAMP, Adenosine 3′,5′-cyclophosphate
• Empirical Formula (Hill Notation): C₁₀H₁₂N₅O₆P
• Numer CAS: 60-92-4
• Masa cząsteczkowa: 329.21
• Beilstein: 52645
• Numer EC: 200-492-9
• Numer MDL: MFCD00005845
• eCl@ss: 32160414
• Identyfikator substancji w PubChem: 24278245
• NACRES: NA.77

Właściwości

• próba: ≥98.5% (HPLC)
• forma: powder
• kolor: white
• mp: 260 °C (dec.) (lit.)
• rozpuszczalność: H₂O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)
• temp. przechowywania: −20°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
• InChI: 1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI key: IVOMOUWHDPKRLL-KQYNXXCUSA-N
• Gene Information: human ... OPRK1(4986)

Opis

Zastosowanie

Adenosine 3′,5′-cyclic monophosphate has been used:

• as cell culture medium supplement in embryonic spinal neurons
• as a component of ringer solution for perfusion studies
• to induce neuroendocrine differentiation in human lung cancer cell lines

Opakowanie

1, 5, 25 g in poly bottle

Działania biochem./fizjol.

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Cechy i korzyści

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu °F: Not applicable
• Temperatura zapłonu °C: Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)