B133

(S)-(−)-Bay K8644

≥98% (HPLC), Ca2+ channel activator, solid

• Synonim(y): S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
• Wzór empiryczny (zapis Hilla): C₁₆H₁₅F₃N₂O₄
• Numer CAS: 98625-26-4
• Masa cząsteczkowa: 356.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891582
• NACRES: NA.77
• MDL number: MFCD00153769
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Nazwa produktu: (S)-(−)-Bay K8644, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: H₂O: slightly soluble, ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
• storage temp.: 2-8°C
• SMILES string: COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
• InChI: 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
• InChI key: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
• Gene Information: human ... ADORA3(140) ; rat ... Adora1(29290), Adora2a(25369)

Opis

General description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺ channel activator. It is an enantiomer of Bay K 8644.

Application

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca²⁺ current, whereas the (+)-Bay K 8644 is a weak Ca²⁺ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bayer AG.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H315,H319
• Ostrzeżenia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves