B2292

O⁶-Benzylguanine

≥98% (TLC), solid, O⁶-alkylguanine DNA alkyltransferase inhiitor

• Wzór empiryczny (zapis Hilla): C₁₂H₁₁N₅O
• Numer CAS: 19916-73-5
• Masa cząsteczkowa: 241.25
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278259
• NACRES: NA.77
• MDL number: MFCD00269931
• Assay: ≥98% (TLC)
• Form: solid

Właściwości

• Nazwa produktu: O⁶-Benzylguanine, ≥98% (TLC), solid
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: solid
• solubility: methanol: 20 mg/mL
• storage temp.: room temp
• SMILES string: Nc1nc(OCc2ccccc2)c3nc[nH]c3n1
• InChI: 1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
• InChI key: KRWMERLEINMZFT-UHFFFAOYSA-N
• Gene Information: human ... MGMT(4255)

Opis

Application

O⁶-Benzylguanine has been used:

• as an inhibitor of methylguanine methyltransferase (MGMT) in glioblastoma stem cell
• as a O6-alkylguanine-alkyltransferase (AGT) enzyme inhibitor in embryonic stem cells prior to N-ethyl-N-nitrosourea(ENU) treatment
• as an inhibitor of AGT in growth inhibition assays of HL-60 human promyelocytic leukemia cells

Biochem/physiol Actions

O⁶-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

O(6)-benzylguanine is an antineoplastic agent that binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), resulting in inhibition of AGT-mediated DNA repair. It is widely used in various DNA repair mechanism studies and potentiates the effects of other chemotherapeutic agents that damage DNA.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral