B8810

BAY 41-2272

≥97% (HPLC)

• Synonim(y): 3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine
• Wzór empiryczny (zapis Hilla): C₂₀H₁₇FN₆
• Numer CAS: 256376-24-6
• Masa cząsteczkowa: 360.39
• NACRES: NA.77
• PubChem Substance ID: 24892096
• UNSPSC Code: 12352200
• MDL number: MFCD06411391
• eCl@ss: 32129103
• Assay: ≥97% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to light brown
• mp: 210.5-211.4 °C
• solubility: DMSO: 5 mg/mL, clear (warmed)
• originator: Bayer
• storage temp.: 2-8°C
• SMILES string: Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35
• InChI: 1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
• InChI key: ATOAHNRJAXSBOR-UHFFFAOYSA-N

Opis

Application

BAY 41-2272 has been used for the stimulation of guanylate cyclase in heart and neurons.

Biochem/physiol Actions

BAY 41-2272 is an activator of soluble guanylate cyclase at a novel, NO-independent regulatory site. BAY 41-2272 is the first product that stimulates sGC through a non-NO mechanism. BAY 41-2272 inhibits platelet aggregation and induces vasorelaxation without nitrate tolerance.

BAY 41-2272 is an activator of soluble guanylate cyclase; stimulates sGC through a non-NO mechanism; inhibits platelet aggregation, and induces vasorelaxation without nitrate tolerance.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves