BX-0200-30

Human Midbrain Dopaminergic Neurons

Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

• Synonim(y): mDA Neurons, BrainXell
• Biological source: human (iPSC line)

Właściwości

• biological source: human (iPSC line)
• form: frozen liquid
• packaging: vial of 1 (contains ≥1 million cells)
• technique(s): cell culture | mammalian: suitable
• shipped in: liquid nitrogen
• storage temp.: -140 to -196°C

Opis

General description

Human iPSC-Derived Midbrain Dopaminergic Neurons. Required supplements for the final cell differentiation and maturation (sold separately): BX-2200-100uL. Dopaminergic neurons are a subtype of neurons that release dopamine as their primary neurotransmitter. Important for various neurological functions including motor coordination and executive function, dopaminergic neurons are a critical part of the central nervous system (CNS). Dopaminergic neurons can be found in the midbrain, and have been a crucial model for the study of regenerative medicine and the development of novel therapeutics for and understand of Parkinson’s disease, Huntington’s disease, ADHD, addiction, and epilepsy. Primary neurotransmitter released: dopamine.

Application

Function: Dopaminergic neurons actively release and uptake dopamine, reflecting their functional maturity. They display both spontaneous and stimulus-evoked electrical activity, making them ideal for electrophysiological applications. Importantly, they are validated for use with microelectrode array (MEA) platforms, allowing researchers to track neuronal network behavior and evaluate how different compounds influence firing patterns.

Features and Benefits

Marker Expression: Fully differentiated Midbrain Dopaminergic Neurons consist of cells derived from human iPSCs that have been induced to neuroepithelial cells, patterned to midbrain floorplate progenitors and differentiated to midbrain dopaminergic neurons. The resulting cell populations contain 50% TH+ cells (a marker for dopaminergic cells).

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08,GHS05
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H302,H311,H317,H318,H361f,H412
• Ostrzeżenia: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Sens. 1
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable