C3118

CPNQ

≥98% (HPLC), solid

• Synonim(y): 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, B2
• Wzór empiryczny (zapis Hilla): C₂₀H₁₇ClN₄O₃
• Numer CAS: 115687-05-3
• Masa cząsteczkowa: 396.83
• NACRES: NA.77
• PubChem Substance ID: 329775023
• UNSPSC Code: 12352202
• MDL number: MFCD02039810
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: brown
• solubility: H₂O: insoluble <2 mg/mL, DMSO: >5 mg/mL
• storage temp.: 2-8°C
• SMILES string: [O-][N+](=O)c1ccc(N2CCN(CC2)C(=O)c3ccc(Cl)cc3)c4cccnc14
• InChI: 1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2
• InChI key: KLNPVNZJCWIQSK-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

CPNQ is a promoter of polyQ and α-synuclein inclusion formation and rescuer of Htt proteosomal dysfunction and α-synuclein toxicity.

Misfolded proteins accumulate in many neurodegenerative diseases, including huntingtin in Huntington′s disease and alpha-synuclein in Parkinson′s disease. The disease-causing proteins can take various conformations and are prone to aggregate and form larger cytoplasmic or nuclear inclusions. CPNQ (B2) was identified as a compound that promotes inclusion formation in cellular models of both Huntington′s disease and Parkinson′s disease. Despite the aggregate-forming specifics the compound prevents huntingtin-mediated proteasome dysfunction and reduces alpha-synuclein-mediated toxicity. These results demonstrate that compounds that increase inclusion formation may actually lessen cellular pathology in both Huntington′s and Parkinson′s diseases, suggesting a therapeutic approach for neurodegenerative diseases caused by protein misfolding. The ability of B2 to prevent toxicity, despite increasing inclusions, suggests that inclusions are beneficial rather than toxic, which will be further explored as the molecular target and mechanism. CPNQ (B2) is a desirable tool for both Huntington′s and Parkinson′s research.

Other Notes

Product is air sensitive.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H315,H319,H335
• Ostrzeżenia: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges