This product is a mixture of the CA-I and CA-I isozymes. The ratio has not been determined.
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C3934
Carbonic Anhydrase from bovine erythrocytes
lyophilized powder, ≥2,000 W-A units/mg protein
Synonim(y):
Carbonate Dehydratase, Carbonate Hydrolyase
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
100 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2020,00 zł |
500 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 7890,00 zł |
Informacje o tej pozycji
Numer CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-576-6
MDL number:
Numer WE:
Specific activity:
≥2,000 W-A units/mg protein
Biological source:
bovine erythrocytes
2020,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
bovine erythrocytes
Quality Segment
form
lyophilized powder
specific activity
≥2,000 W-A units/mg protein
mol wt
30 kDa
application(s)
diagnostic assay manufacturing
storage temp.
2-8°C
Application
Carbonic anhydrase from bovine erythrocytes (BCA) has been used to study the effect of removal of enzyme-bound metal ion, Zn2+, on aggregation behavior of the enzyme. Removal of metal ion by a chelator such as EDTA enhances the propensity of the enzyme to adopt the molten-globule state. This state of the enzyme is found to bind to the chaperone-like α-crystallin and prevent aggregation. The enzyme from Sigma has been immobilized to electrochemical transducers in order to obtain develop an analytical device for dissolved CO2 measurement. It has also been used for the thermodynamic analysis of conformational changes in BCA.
Biochem/physiol Actions
Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital physiological and pathological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications for various pathologies such as glaucoma, epilepsy and Parkinson′s disease.
Other Notes
One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0°C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)
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Ta pozycja | |||
|---|---|---|---|
| description lyophilized powder, ≥2,000 W-A units/mg protein | description ≥95% (SDS-PAGE), specific activity ≥3,500 W-A units/mg protein, lyophilized powder | description lyophilized powder, ≥2,000 W-A units/mg protein | description For use as a marker in SDS-PAGE |
| biological source bovine erythrocytes | biological source bovine erythrocytes | biological source - | biological source bovine erythrocytes |
| specific activity ≥2,000 W-A units/mg protein | specific activity ≥3,500 W-A units/mg protein | specific activity ≥2,000 W-A units/mg protein | specific activity - |
| application(s) diagnostic assay manufacturing | application(s) - | application(s) - | application(s) - |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| mol wt 30 kDa | mol wt - | mol wt - | mol wt ~29 kDa |
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Słowo ostrzegawcze
Danger
Kody zagrożeń
Ostrzeżenia
Hazard Classifications
Resp. Sens. 1
Klasa składowania
11 - Combustible Solids
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
PPE (środki ochrony indywidualnej)
Eyeshields, Gloves, type N95 (US)
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Dear who is concern, I would like to know which isoform of carbonic anhydrase this is.
1 answer-
Helpful?
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What is the purity of Product C3934, Carbonate Dehydratase?
1 answer-
Since C3934 is a mixture of isoforms, no purity claim is made. The product is packaged and offered based on its enzymatic activity.
Helpful?
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What is the molecular weight of Product C3934, Carbonate Dehydratase?
1 answer-
Because there are a number of closely related isoforms, the molecular weight typically used is approximately 30 kDa. This product is expected to be a mixture of isoforms.
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Can stock solutions of Product C3934, Carbonate Dehydratase, be made and stored?
1 answer-
Carbonic anhydrase solutions can be prepared in water or buffer at concentrations up to 10 mg/mL. It is common for there to be some particulates or haziness in the solution. No data on solution stability has been collected by Sigma-Aldrich, so we recommend solutions be prepared fresh for use.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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