C4911

Chlorothiazide

synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder

• Synonim(y): 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Wzór empiryczny (zapis Hilla): C₇H₆ClN₃O₄S₂
• Numer CAS: 58-94-6
• Masa cząsteczkowa: 295.72
• NACRES: NA.77
• PubChem Substance ID: 24278150
• UNSPSC Code: 12352202
• EC Number: 200-404-9
• MDL number: MFCD00058576

Właściwości

• Nazwa produktu: Chlorothiazide, thiazide diuretic
• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• mp: >300 °C
• solubility: DMF: 50 mg/mL, clear, colorless to very faintly yellow
• storage temp.: 2-8°C
• SMILES string: O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
• InChI: 1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
• InChI key: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• Gene Information: human ... CA1(759), CA4(762), SLC12A3(6559)

Opis

General description

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.

Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.

One of the first in the thiazide class of diuretics.

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H317,H334
• Ostrzeżenia: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves