C5259

Carbamyl-β-methylcholine chloride

Name: Carbamyl-β-methylcholine chloride
Brand: SIGMA
Price: 949 PLN

≥99% (TLC), crystalline

Synonim(y):

Bethanechol chloride

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5 G

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Informacje o tej pozycji

Wzór liniowy:

C₇H₁₇N₂O₂Cl

Numer CAS:

590-63-6

Masa cząsteczkowa:

196.68

NACRES:

NA.25

PubChem Substance ID:

24277823

UNSPSC Code:

41116107

EC Number:

209-686-8

MDL number:

MFCD00055224

Assay:

≥99% (TLC)

Form:

crystalline

Quality level:

100

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InChI key

AIRHOJQHGLTTTB-UHFFFAOYSA-N

InChI

1S/C7H17N2O2.ClH/c1-6(11-7(8)10)5-9(2,3)4;/h6H,5H2,1-4H3,(H2,8,10);1H

SMILES string

Cl.CC(C[N](C)(C)C)OC(N)=O

assay

≥99% (TLC)

form

crystalline

color

white

solubility

H₂O: 1.7 g/mL (stable for several days at 4°C.), ethanol: 80 mg/mL (stable for several days at 4°C.)

storage temp.

2-8°C

Quality Level

100

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Ta pozycja	T4376	A0779	B107
Sigma-Aldrich C5259 Carbamyl-β-methylcholine chloride	Sigma-Aldrich T4376 N-p-Tosyl-L-phenylalanine chloromethyl ketone	Sigma-Aldrich A0779 p-Aminoclonidine hydrochloride	Sigma-Aldrich B107 L-BMAA hydrochloride
assay ≥99% (TLC)	assay ≥97% (TLC)	assay -	assay ≥97% (NMR)
form crystalline	form powder	form solid	form powder
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility H₂O: 1.7 g/mL (stable for several days at 4°C.), ethanol: 80 mg/mL (stable for several days at 4°C.)	solubility DMSO: >10 mg/mL (stable for several months at 4°C.), ethanol: 20 mg/mL	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL (Solutions may be stored for several days at 4 °C), boiling water: 100 mg/mL (Solutions may be stored for several days at 4 °C), 0.1 M HCl: soluble (Solutions may be stored for several days at 4 °C), methanol: soluble (Solutions may be stored for several days at 4 °C)	solubility H₂O: soluble (solutions may be stored for several days at 4 °C)
color white	color white	color white	color white to beige

General description

Muscarinic acetylcholine receptor agonist that is not a substrate for acetylcholinesterase.

Application

Carbamyl-β-methylcholine chloride has been used in western blotting and bactericidal assay.[1] It has also been used in concentration-response studies with isolated atrial preparation.[2]

Biochem/physiol Actions

Carbamyl-β-methylcholine has a selective action on urinary bladder and intestine.[3] It induces smooth muscle tension in the bladder.[4] Its main function is to induce detrusor muscle action, mediated by postganglionic parasympathetic effector cells.[5] Nausea, flushing, sweating, abdominal cramps are some of the side effect caused by carbamyl-β-methylcholine.[6]

Disclaimer

Hygroscopic.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Odwiedź Bibliotekę dokumentów

Generation of a human urinary bladder smooth muscle cell line.

Zheng Y, Chang S, Boopathi E, et al.

In Vitro Cellular & Developmental Biology, 48, 84-96 (2012)

Adult and Pediatric Urology, 1, 1127-1127 (2002)

Anti-ulcerogenic mechanisms of the sesquiterpene lactone onopordopicrin-enriched fraction from Arctium lappa L. (Asteraceae): role of somatostatin, gastrin, and endogenous sulfhydryls and nitric oxide.

Ana Beatriz Albino de Almeida et al.

Journal of medicinal food, 15(4), 378-383 (2011-12-24)

Arctium lappa L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. The mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from A.

Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function.

Jagmohan Singh et al.

Gastroenterology, 143(5), 1308-1318 (2012-08-07)

Patients with systemic sclerosis (SSc) have impairments in gastrointestinal smooth muscle function. The disorder has been associated with circulating antibodies to cholinergic muscarinic the type-3 receptor (M(3)-R). We investigated whether it is possible to neutralize these antibodies with pooled human

Role of hydrogen sulfide as a gasotransmitter in modulating contractile activity of circular muscle of rat jejunum.

Munenori Nagao et al.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 16(2), 334-343 (2011-11-08)

Our aim was to determine mechanisms of action of the gasotransmitter hydrogen sulfide (H(2)S) on contractile activity in circular muscle of rat jejunum. Jejunal circular muscle strips were prepared to measure isometric contractions. Effects of sodium hydrosulfide (NaHS), a H(2)S

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