C9369

CCT007093

≥98% (HPLC), powder, yellow

• Synonim(y): (2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone
• Wzór empiryczny (zapis Hilla): C₁₅H₁₂OS₂
• Numer CAS: 176957-55-4
• Masa cząsteczkowa: 272.39
• NACRES: NA.77
• PubChem Substance ID: 329775204
• UNSPSC Code: 12352200
• MDL number: MFCD00121546
• Assay: ≥98% (HPLC)
• Form: powder, yellow

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder, yellow
• solubility: DMSO: >3 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3
• InChI: 1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+
• InChI key: KPFZCKDPBMGECB-WGDLNXRISA-N

Opis

Application

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

Biochem/physiol Actions

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg²⁺/Mn²⁺ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.

CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.

CCT007093 is an effective protein phosphatase, Mg²⁺/Mn²⁺ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H315,H319,H335
• Ostrzeżenia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Narządy docelowe: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves