D3630

Diphenhydramine hydrochloride

≥98% (HPLC), H1 histamine receptor antagonist, powder

• Synonim(y): 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₇H₂₁NO · HCl
• Numer CAS: 147-24-0
• Masa cząsteczkowa: 291.82
• NACRES: NA.77
• PubChem Substance ID: 24277771
• UNSPSC Code: 12352116
• EC Number: 205-687-2
• MDL number: MFCD00012479
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Diphenhydramine hydrochloride, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• originator: Johnson & Johnson
• SMILES string: Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
• InChI: 1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
• InChI key: PCHPORCSPXIHLZ-UHFFFAOYSA-N
• Gene Information: human ... HRH1(3269)

Opis

Application

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies

Biochem/physiol Actions

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves