D4505

5,5-Diphenylhydantoin sodium salt

≥99%

• Synonim(y): 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Wzór liniowy: C₁₅H₁₁N₂O₂Na
• Numer CAS: 630-93-3
• Masa cząsteczkowa: 274.25
• NACRES: NA.77
• PubChem Substance ID: 24277707
• UNSPSC Code: 12352200
• EC Number: 211-148-2
• MDL number: MFCD00069674
• Assay: ≥99%
• Form: powder

Właściwości

• Quality Segment: 200
• assay: ≥99%
• form: powder
• solubility: aqueous base: soluble
• SMILES string: [Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
• InChI key: FJPYVLNWWICYDW-UHFFFAOYSA-M
• Gene Information: human ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

Opis

General description

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

Application

5,5-Diphenylhydantoin sodium salt has been used:

• in the cream preparation for treating burn wounds
• in seizure behavior testing as an anticonvulsant in Drosophila
• in in vivo embryo toxicity test in mouse embryonic stem cells

Biochem/physiol Actions

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes.

Features and Benefits

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H317,H361
• pcodes: P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges