D7191

Dibenzylfluorescein

• Synonim(y): DBF
• Wzór empiryczny (zapis Hilla): C₃₄H₂₄O₅
• Masa cząsteczkowa: 512.55
• UNSPSC Code: 12171500
• PubChem Substance ID: 329798844
• MDL number: MFCD13184323

Właściwości

• assay: 99-102% (NMR)
• Quality Segment: 200
• form: solid
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O=C1C=CC2=C(c3ccc(OCc4ccccc4)cc3OC2=C1)c5ccccc5C(=O)OCc6ccccc6
• InChI: 1S/C34H24O5/c35-25-15-17-29-31(19-25)39-32-20-26(37-21-23-9-3-1-4-10-23)16-18-30(32)33(29)27-13-7-8-14-28(27)34(36)38-22-24-11-5-2-6-12-24/h1-20H,21-22H2
• InChI key: YZJGKSLPSGPFEV-UHFFFAOYSA-N

Opis

Application

DBF is dealkylated by cytochromes P450 (especially CYP2C8, CYP2C9, CYP2C19, and CYP3A) to form a fluorescein ester. Dibenzylfluorescein was reported to be suitable for in vitro assessment of the initial screening of CYP3A4-
mediated drug interactions. The fluorescent fluorescein product can be quantitated after the addition of base, which hydrolyzes the ester and increases the pH for optimal fluorescein fluorescence detection.

DBF is dealkylated by cytochromes P450 (especially CYP2C8, CYP2C9, CYP2C19, and CYP3A) to form a fluorescein ester. The fluorescent fluorescein product can be quantitated after the addition of base, which hydrolyzes the ester and increases the pH for optimal fluorescein fluorescence detection.

Other Notes

Dibenzylfluorescein is light sensitive and should be protected from direct sunlight or UV sources.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves