E7138

Ethosuximide

T-type calcium channel antagonist

• Synonim(y): 2-Ethyl-2-methylsuccinimide
• Wzór empiryczny (zapis Hilla): C₇H₁₁NO₂
• Numer CAS: 77-67-8
• Masa cząsteczkowa: 141.17
• NACRES: NA.77
• PubChem Substance ID: 24278423
• UNSPSC Code: 12352111
• EC Number: 201-048-7
• MDL number: MFCD00072123
• eCl@ss: 32150917

Właściwości

• Nazwa produktu: Ethosuximide,
• Quality Segment: 100
• solubility: ethanol: 100 mg/mL
• SMILES string: O=C1NC(CC1(C)CC)=O
• InChI: 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
• InChI key: HAPOVYFOVVWLRS-UHFFFAOYSA-N
• Gene Information: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Opis

Application

Ethosuximide has been used:

• to confirm its effect on spike wave discharges (SWD) in rats
• to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
• as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves