E7265

Big Endothelin 39 rat

≥97% (HPLC)

• Wzór empiryczny (zapis Hilla): C₁₉₂H₂₉₂N₅₀O₅₈S₅
• Numer CAS: 135842-15-8
• Masa cząsteczkowa: 4389.00
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00151519
• Assay: ≥97% (HPLC)

Właściwości

• Quality Segment: 200
• assay: ≥97% (HPLC)
• UniProt accession no.: P22388
• storage temp.: −20°C
• Gene Information: rat ... Edn1(24323)

Opis

General description

Big endothelin-1 is a 39 amino acid peptide, which is synthesized and secreted by vascular smooth muscle and endothelium cells. It is produced as an inactive enzyme, and is cleaved and activated by serine and aspartic proteases and metalloproteinases. Activated form is called ET-1, which is a potent vasoconstrictor. ET-1 is also produced by the action of endothelin converting enzyme (ECE) on big-ET-1. In guinea pigs, big-ET-1 causes the release of prostanoids and thromboxanes.

Application

Big Endothelin 39 rat has been used for charting of a standard curve in the study of the role of ET-1 in ventricular dilatation.

Biochem/physiol Actions

Precursor of Endothelin-1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H300 + H330
• Ostrzeżenia: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)