E9406

Epirubicin hydrochloride

≥90% (HPLC)

• Synonym(s): 4′-Epidoxorubicin hydrochloride, Epidoxorubicin hydrochloride
• Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₁ · HCl
• CAS Number: 56390-09-1
• Molecular Weight: 579.98
• Numer EC: 260-145-2
• Numer MDL: MFCD00941448
• Identyfikator substancji w PubChem: 329799084
• NACRES: NA.85

Properties

• pochodzenie biologiczne: synthetic
• Poziom jakości: 100
• próba: ≥90% (HPLC)
• forma: powder
• kolor: red to deep red
• rozpuszczalność: H₂O: soluble
• spektrum działania antybiotyku: neoplastics
• Tryb działania: DNA synthesis | interferes; enzyme | inhibits
• temp. przechowywania: −20°C
• SMILES string: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
• InChI key: MWWSFMDVAYGXBV-FGBSZODSSA-N

Description

Zastosowanie

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Opakowanie

5, 10 mg in glass bottle

Działania biochem./fizjol.

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Safety Information

• piktogramy: GHS07,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302 - H340 - H350 - H360
• Zwroty wskazujące środki ostrożności: P201 - P301 + P312 + P330 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Kod klasy składowania: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves