EPS003

CUDC 101

A potent inhibitor of HDACs and receptor tyrosine kinases

• Synonim(y): 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide, Heptanamide, 7-[[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxy
• Wzór empiryczny (zapis Hilla): C₂₄H₂₆N₄O₄
• Numer CAS: 1012054-59-9
• Masa cząsteczkowa: 434.49
• MDL number: MFCD15528940
• UNSPSC Code: 12352200
• NACRES: NA.41
• Assay: ≥98% (HPLC)

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• color: white
• solubility: DMSO: soluble
• storage temp.: −20°C
• SMILES string: N(O)C(=O)CCCCCCOc1cc2c(ncnc2Nc3cc(ccc3)C#C)cc1OC
• InChI: 1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
• InChI key: PLIVFNIUGLLCEK-UHFFFAOYSA-N

Opis

General description

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC50 values of 4.4, 2.4, and 15.7 nM, respectively.

Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable