Some cells, and in particular cancer cells, may be resistant to 5-fluorouracil. Please see this paper Huanwen, W., et al., Molecular Cancer, 8, 125 (2009) which addresses this observation, as well as references 16 and 30 in this publication.If the cells are treated with the closely related gemcitabine (Sigma-Aldrich Product G6423), and cell growth is not inhibited by that drug either, you will have shown that the "problem" is with the cell line, and not with the drug(s).
Przejdź do
F8423
Fluorouracil
meets USP testing specifications
Synonim(y):
5-Fluorouracil, 2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1010,00 zł 858,50 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C4H3FN2O2
Numer CAS:
Masa cząsteczkowa:
130.08
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
EC Number:
200-085-6
Beilstein/REAXYS Number:
127172
MDL number:
858,50 zł
Cena katalogowa1010,00 złZaoszczędź 15%Promocja dostępna wyłącznie online
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Pozwól nam pomócQuality Segment
agency
USP/NF, meets USP testing specifications
mp
282-286 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
FC1=CNC(=O)NC1=O
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
Gene Information
human ... TYMS(7298)
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Ta pozycja | |||
|---|---|---|---|
| description meets USP testing specifications | description United States Pharmacopeia (USP) Reference Standard | description Pharmaceutical Secondary Standard; Certified Reference Material | description European Pharmacopoeia (EP) Reference Standard |
| Quality Level 200 | Quality Level - | Quality Level 300 | Quality Level - |
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical | application(s) cleaning products | application(s) pharmaceutical |
| agency USP/NF, meets USP testing specifications | agency USP | agency traceable to Ph. Eur. F0250000, USP 12790000 | agency - |
| mp 282-286 °C (dec.) (lit.) | mp 282-286 °C (dec.) (lit.) | mp 282-286 °C (dec.) (lit.) | mp 282-286 °C (dec.) (lit.) |
| Gene Information human ... TYMS(7298) | Gene Information human ... TYMS(7298) | Gene Information human ... TYMS(7298) | Gene Information human ... TYMS(7298) |
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Słowo ostrzegawcze
Danger
Kody zagrożeń
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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Why does the 5-Fluorouracil have no effect on my cell line, even at micromolar concentrations that should be more than high enough?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Do you have 5-FU (5-Fluorouracil) for injection? If not, how can I prepare it from the powder?
1 answer-
Sigma-Aldrich lists several fluorouracil products, but we do not offer Fluorouracil for injection. Our 5-Fluorouracil (5-FU) products cannot be given to human patients. (Note that although Product F8423 meets USP testing specifications, it is not a pharmaceutical grade or PharmaGrade product.)Having said that, a solution for injection into research animals could be prepared the same way as the Fluorouracil Injection, USP is. According to the drugs.com, "Fluorouracil Injection, USP, an antineoplastic anti-metabolite, is a colorless to yellow aqueous sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains: 50 mg fluorouracil; pH is adjusted to 8.6 to 9.4 with sodium hydroxide".
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