G2879

Glycine hydrochloride

≥99% (HPLC), NMDA receptors regulator, powder

• Synonim(y): Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Wzór liniowy: H₂NCH₂CO₂H · HCl
• Numer CAS: 6000-43-7
• Masa cząsteczkowa: 111.53
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895108
• NACRES: NA.32
• EC Number: 227-841-8
• MDL number: MFCD00012872

Właściwości

• Nazwa produktu: Glycine hydrochloride, ≥99% (HPLC)
• Quality Segment: 300
• assay: ≥99% (HPLC)
• form: powder
• mol wt: 111.53
• storage condition: (Tightly closed Dry)
• concentration: ≤100%
• technique(s): immunohistochemistry: suitable
• mp: 176-180 °C (lit.)
• solubility: water: 0.5 g/mL, clear, colorless
• storage temp.: room temp
• SMILES string: Cl.NCC(O)=O
• InChI: 1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
• InChI key: IVLXQGJVBGMLRR-UHFFFAOYSA-N

Opis

General description

Research area: Neuroscience

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.

Glycine hydrochloride has been used:

• in the preparation of glycine-HCl buffer
• to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
• to regenerate the sensor to elute the bound C-reactive protein (CRP)

Biochem/physiol Actions

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H314
• Ostrzeżenia: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1
• Klasa składowania: 8A - Combustible corrosive hazardous materials
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)