H9538

HNE-DMA

hexane solution, ≥85% (GC)

• Synonim(y): (E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA
• Wzór empiryczny (zapis Hilla): C₁₁H₂₂O₃
• Masa cząsteczkowa: 202.29
• NACRES: NA.77
• PubChem Substance ID: 24724506
• UNSPSC Code: 12352200
• MDL number: MFCD07370138
• Assay: ≥85% (GC)
• Form: hexane solution

Właściwości

• Quality Segment: 100
• assay: ≥85% (GC)
• form: hexane solution
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: CCCCCC(O)\C=C\C(OC)OC
• InChI: 1S/C11H22O3/c1-4-5-6-7-10(12)8-9-11(13-2)14-3/h8-12H,4-7H2,1-3H3/b9-8+
• InChI key: ATGIHMSJAARJTF-CMDGGOBGSA-N

Opis

Biochem/physiol Actions

Stable form of HNE; toxic second messenger of free radicals.

Preparation Note

To prepare HNE from HNE-DMA: evaporate the hexane under a gentle stream of nitrogen at room temperature. Working at 4 °C, add 1 ml (5 mg size) or 0.4 ml (2 mg size) of 1 mM cold HCl and stir for 45 minutes, or alternatively, close the vial and shake for 30 minutes. Upon hydrolysis, the initially cloudy solution becomes almost clear. This solution now has a pH of ∼3, contains ∼5 mg (5 mg size) or ∼2 mg (2 mg size) of the aldehyde (HNE), and is stable for at least 24 hours if kept at 4 °C. 6.8 mg HNE-DMA in 1 mL of hexane solution, giving 5 mg of HNE after hydrolysis.It is recommended that the freshly prepared HNE solution be used immediately.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS08,GHS07,GHS09
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H225,H304,H315,H336,H361f,H372,H411
• Ostrzeżenia: P202 - P210 - P273 - P301 + P310 - P303 + P361 + P353 - P331
• Hazard Classifications: Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
• Narządy docelowe: Central nervous system, Nervous system
• Klasa składowania: 3 - Flammable liquids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): -14.8 °F - closed cup
• Temperatura zapłonu (°C): -26 °C - closed cup
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter