I2765

Ibotenic acid

~95% (TLC), solid, neurotoxin

• Synonim(y): α-Amino-3-hydroxy-5-isoxazoleacetic acid
• Wzór empiryczny (zapis Hilla): C₅H₆N₂O₄
• Numer CAS: 2552-55-8
• Masa cząsteczkowa: 158.11
• UNSPSC Code: 12352209
• PubChem Substance ID: 24277994
• NACRES: NA.32
• MDL number: MFCD00069294
• Assay: ~95%
• Form: solid

Właściwości

• Nazwa produktu: Ibotenic acid, ~95%, solid
• assay: ~95%
• Quality Segment: 100
• form: solid
• color: white
• solubility: H₂O: 1 mg/mL, clear, colorless (with sonication), 0.1 M NaOH: 10.7 mg/mL, 0.1 M HCl: 4.7 mg/mL
• SMILES string: NC(C(O)=O)C1=CC(=O)NO1
• InChI: 1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
• InChI key: IRJCBFDCFXCWGO-UHFFFAOYSA-N
• Gene Information: rat ... Grm1(24414), Grm2(24415)

Opis

Application

Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.

Ibotenic acid has been used as a neurontoxin in rats. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons.

Biochem/physiol Actions

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin.

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.

Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT). It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality.

Disclaimer

Hygroscopic

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301
• Ostrzeżenia: P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges