I4659

ICRF-193

synthetic (organic), ≥95%, topoisomerase II inhibitor, solid,powder or flakes

• Synonim(y): meso-4,4′-(3,2-Butanediyl)-bis(2,6-piperazinedione)
• Wzór empiryczny (zapis Hilla): C₁₂H₁₈N₄O₄
• Numer CAS: 21416-88-6
• Masa cząsteczkowa: 282.30
• UNSPSC Code: 12352204
• PubChem Substance ID: 24896062
• NACRES: NA.77
• MDL number: MFCD01702964
• Assay: ≥95%
• Form: powder or flakes, solid

Właściwości

• Nazwa produktu: ICRF-193, apoptosis inducer, arabinosidase substrate
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥95%
• form: powder or flakes, solid
• solubility: DMSO: 4 mg/mL
• storage temp.: −20°C
• SMILES string: C[C@@H]([C@@H](C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C12H18N4O4/c1-7(15-3-9(17)13-10(18)4-15)8(2)16-5-11(19)14-12(20)6-16/h7-8H,3-6H2,1-2H3,(H,13,17,18)(H,14,19,20)/t7-,8+
• InChI key: OBYGAPWKTPDTAS-OCAPTIKFSA-N

Opis

General description

ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable complex.

Application

ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis.

Biochem/physiol Actions

ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells.^, ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks.

ICRF-193 helps in the enhancement of cell cycle without chromosome segregation. It is considered as an important drug for chemo-differentiation therapy against acute promyelocytic leukemia (APL). ICRF-193 serves as an inducer of differentiation between anticancer drugs.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H301,H317
• Ostrzeżenia: P280 - P301 + P310 + P330 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Skin Sens. 1
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Faceshields, Gloves